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pentobarbital will lessen the level or effect of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or impact of carbamazepine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.Anticoagulants: Phenobarbital lowers the plasma amounts of dicumarol (name Earlier